Verteporfin ocular photodynamic therapy

被引：21

作者：

Bakri, SJ ^{[1
]}

Kaiser, PK ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Cole Eye Inst, Cleveland, OH 44195 USA

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2004年 / 5卷 / 01期

关键词：

choroidal neovascularisation; macular degeneration; ocular histoplasmosis; pathologic myopia; photodynamic therapy; verteporfin; visudyne;

D O I：

10.1517/14656566.5.1.195

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article reviews the pharmacotherapeutics of verteporfin (Visudyne(R), Novartis Pharma AG) used in ocular photodynamic therapy. The chemistry, pharmacokinetics and pharmacodynamics of the drug are reviewed. The article highlights and summarises the results of the multi-centre, randomised, controlled clinical trials with verteporfin to treat subfoveal choroidal neovascularisation in age-related macular degeneration, ocular histoplasmosis syndrome and pathologic myopia. In addition, the safety profile and side effects of verteporfin are discussed.

引用

页码：195 / 203

页数：9

共 41 条

[1]

[Anonymous], 1991, Arch Ophthalmol, V109, P1220

[2]

Arnold J, 2001, AM J OPHTHALMOL, V131, P541

[3] Photodynamic therapy of choroidal hemangioma: two case reports [J].

Barbazetto, I ;

Schmidt-Erfurth, U .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2000, 238 (03) :214-221

[4] SUBRETINAL NEOVASCULARIZATION IN SENILE MACULAR DEGENERATION [J].

BERKOW, JW .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1984, 97 (02) :143-147

[5] Effect of lesion size, visual acuity, and lesion composition on visual acuity change with and without verteporfin therapy for choroidal neovascularization secondary to age-related macular degeneration: TAP and VIP report no. 1 [J].

Blinder, KJ ;

Bradley, S ;

Bressler, NM ;

Bressler, SB ;

Donati, G ;

Hao, Y ;

Ma, C ;

Menchini, U ;

Miller, J ;

Potter, MJ ;

Pournaras, JC ;

Reaves, A ;

Rosenfeld, PJ ;

Strong, HA ;

Stur, M ;

Su, XY ;

Virgili, G .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2003, 136 (03) :407-418

[6] Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia - 2-year results of a randomized clinical Trial - VIP report no. 3 [J].

Blinder, KJ ;

Blumenkranz, MS ;

Bressler, NM ;

Bressler, SB ;

Donati, G ;

Lewis, H ;

Lim, JI ;

Menchini, U ;

Miller, JW ;

Mones, JM ;

Potter, MJ ;

Pournaras, C ;

Reaves, A ;

Rosenfeld, P ;

Schachat, AP ;

Schmidt-Erfurth, U ;

Sickenberg, M ;

Singerman, LJ ;

Slakter, J ;

Strong, HA ;

Virgili, G ;

Williams, GA .

OPHTHALMOLOGY, 2003, 110 (04) :667-673

[7]

Blumenkranz MS, 2001, ARCH OPHTHALMOL-CHIC, V119, P198

[8] Verteporfin infusion-associated pain [J].

Borodoker, N ;

Spaide, RF ;

Maranan, L ;

Murray, J ;

Freund, KB ;

Slakter, JS ;

Sorenson, JA ;

Yannuzzi, LA ;

Guyer, DR ;

Fisher, YL .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 133 (02) :211-214

[9]

Bressler NM, 2000, ARCH OPHTHALMOL-CHIC, V118, P488

[10]

Bressler NM, 2002, ARCH OPHTHALMOL-CHIC, V120, P1307

← 1 2 3 4 5 →