Reverse Cholesterol Transport Revisited Contribution of Biliary Versus Intestinal Cholesterol Excretion

被引：101

作者：

Brufau, Gemma ^{[1
]}

Groen, Albert K. ^{[1
,2
]}

Kuipers, Folkert ^{[1
,2
]}

机构：

[1] Univ Groningen, Dept Pediat, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, NL-9700 AB Groningen, Netherlands

[2] Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, NL-9700 AB Groningen, Netherlands

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 08期

关键词：

ABC transporter; atherosclerosis; genetically altered mice; lipoproteins; macrophages; HIGH-DENSITY-LIPOPROTEIN; LIVER-X-RECEPTOR; BINDING CASSETTE TRANSPORTERS; FECAL STEROID-EXCRETION; ACUTE-PHASE RESPONSE; IN-VIVO; A-I; SR-BI; ANTIINFLAMMATORY PROPERTIES; PLASMA-LIPOPROTEINS;

D O I：

10.1161/ATVBAHA.108.181206

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification. (Arterioscler Thromb Vasc Biol. 2011;31:1726-1733.)

引用

收藏

页码：1726 / 1733

页数：8

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