Review: Emerging concepts in the pathogenesis of tendinopathy

被引:80
作者
Dean, Benjamin J. F. [1 ]
Dakin, Stephanie G. [1 ]
Millar, Neal L. [2 ]
Carr, Andrew J. [1 ]
机构
[1] Univ Oxford, Botnar Res Ctr, NDORMS, Windmill Rd, Oxford OX3 7LD, England
[2] Vet & Life Sci Univ Glasgow, Coll Med, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland
来源
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2017年 / 15卷 / 06期
基金
英国惠康基金;
关键词
Tendon; Tendinopathy; Tendinitis; Inflammation; Pain; Pathogenesis; ROTATOR CUFF DISEASE; MIDPORTION ACHILLES TENDINOPATHY; PAINFUL HUMAN TENDINOPATHY; RAT SUPRASPINATUS TENDON; IMPINGEMENT SYNDROME; EXTRACELLULAR-MATRIX; GLUTAMATE RECEPTORS; BASIC SCIENCE; OVERUSE; TISSUE;
D O I
10.1016/j.surge.2017.05.005
中图分类号
R61 [外科手术学];
学科分类号
100210 [外科学];
摘要
Tendinopathy is a common clinical problem and has a significant disease burden attached, not only in terms of health care costs, but also for patients directly in terms of time off work and impact upon quality of life. Controversy surrounds the pathogenesis of tendinopathy, however the recent systematic analysis of the evidence has demonstrated that many of the claims of an absence of inflammation in tendinopathy were more based around belief than robust scientific data. This review is a summary of the emerging research in this topical area, with a particular focus on the role of neuronal regulation and inflammation in tendinopathy. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland.
引用
收藏
页码:349 / 354
页数:6
相关论文
共 76 条
[1]
Al-Sadi Onays, 2011, Muscles Ligaments Tendons J, V1, P68
[2]
In situ microdialysis in tendon tissue:: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain [J].
Alfredson, H ;
Thorsen, K ;
Lorentzon, R .
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 1999, 7 (06) :378-381
[3]
In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee [J].
Alfredson, H ;
Forsgren, S ;
Thorsen, K ;
Lorentzon, R .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2001, 19 (05) :881-886
[4]
Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model [J].
Andersson, Gustav ;
Backman, Ludvig J. ;
Scott, Alexander ;
Lorentzon, Ronny ;
Forsgren, Sture ;
Danielson, Patrik .
BRITISH JOURNAL OF SPORTS MEDICINE, 2011, 45 (13) :1017-1022
[5]
Rat supraspinatus tendon expresses cartilage markers with overuse [J].
Archambault, J. M. ;
Jelinsky, S. A. ;
Lake, S. P. ;
Hill, A. A. ;
Glaser, D. L. ;
Soslowsky, L. J. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2007, 25 (05) :617-624
[6]
Backman LJ, 2011, J MUSCULOSKEL NEURON, V11, P133
[7]
Substance P Is a Mechanoresponsive, Autocrine Regulator of Human Tenocyte Proliferation [J].
Backman, Ludvig J. ;
Fong, Gloria ;
Andersson, Gustav ;
Scott, Alexander ;
Danielson, Patrik .
PLOS ONE, 2011, 6 (11)
[8]
Birch Helen L, 2013, Muscles Ligaments Tendons J, V3, P12, DOI 10.11138/mltj/2013.3.1.012
[9]
Joint Immobilization Reduces the Expression of Sensory Neuropeptide Receptors and Impairs Healing after Tendon Rupture in a Rat Model [J].
Bring, Daniel K. -I ;
Reno, Carol ;
Renstrom, Per ;
Salo, Paul ;
Hart, David A. ;
Ackermann, Paul W. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2009, 27 (02) :274-280
[10]
INNOVATION Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications [J].
Brown, Brian D. ;
Naldini, Luigi .
NATURE REVIEWS GENETICS, 2009, 10 (08) :578-585