Review: Emerging concepts in the pathogenesis of tendinopathy

被引：80

作者：

Dean, Benjamin J. F. ^{[1
]}

Dakin, Stephanie G. ^{[1
]}

Millar, Neal L. ^{[2
]}

Carr, Andrew J. ^{[1
]}

机构：

[1] Univ Oxford, Botnar Res Ctr, NDORMS, Windmill Rd, Oxford OX3 7LD, England

[2] Vet & Life Sci Univ Glasgow, Coll Med, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland

来源：

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2017年 / 15卷 / 06期

基金：

英国惠康基金;

关键词：

Tendon; Tendinopathy; Tendinitis; Inflammation; Pain; Pathogenesis; ROTATOR CUFF DISEASE; MIDPORTION ACHILLES TENDINOPATHY; PAINFUL HUMAN TENDINOPATHY; RAT SUPRASPINATUS TENDON; IMPINGEMENT SYNDROME; EXTRACELLULAR-MATRIX; GLUTAMATE RECEPTORS; BASIC SCIENCE; OVERUSE; TISSUE;

D O I：

10.1016/j.surge.2017.05.005

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Tendinopathy is a common clinical problem and has a significant disease burden attached, not only in terms of health care costs, but also for patients directly in terms of time off work and impact upon quality of life. Controversy surrounds the pathogenesis of tendinopathy, however the recent systematic analysis of the evidence has demonstrated that many of the claims of an absence of inflammation in tendinopathy were more based around belief than robust scientific data. This review is a summary of the emerging research in this topical area, with a particular focus on the role of neuronal regulation and inflammation in tendinopathy. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland.

引用

页码：349 / 354

页数：6

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