Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology

被引：222

作者：

Su, JH ^{[1
]}

Zhao, M

Anderson, AJ

Srinivasan, A

Cotman, CW

机构：

[1] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA

[2] IDUN Pharmaceut Inc, La Jolla, CA 92037 USA

来源：

BRAIN RESEARCH | 2001年 / 898卷 / 02期

关键词：

activated caspase-3; neurofibrillary tangle; senile plaque; neuropathology; Alzheimer's disease; cell death;

D O I：

10.1016/S0006-8993(01)02018-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：350 / 357

页数：8

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