Click chelators for platinum-based anticancer drugs

被引：95

作者：

Maisonial, Aurelie ^{[3
]}

Serafin, Patrycja ^{[3
]}

Traikia, Mounir ^{[3
]}

Debiton, Eric ^{[1
,2
]}

Thery, Vincent ^{[3
]}

Aitken, David J. ^{[4
]}

Lemoine, Pascale ^{[5
,6
]}

Viossat, Bernard ^{[5
,6
]}

Gautier, Arnaud ^{[3
]}

机构：

[1] Univ Clermont 1, INSERM, UMR 484, Lab Pharmacognosie Biotechnol,UFR Pharm, F-63005 Clermont Ferrand, France

[2] Ctr Jean Perrin, F-63005 Clermont Ferrand, France

[3] Univ Blaise Pascal, CNRS, UMR 6504, Lab SEESIB, F-63177 Clermont Ferrand, France

[4] Univ Paris 11, CNRS UMR 8182, Lab SOM ICMMO, F-91405 Orsay, France

[5] Univ Paris 05, Lab Cristallog, Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France

[6] Univ Paris 05, CNRS, RMN Biol UMR 8015, Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2008年 / 02期

关键词：

click chemistry; platinum; chelates; cancer;

D O I：

10.1002/ejic.200700849

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Triazoles from "click chemistry" are convenient ligands for the formation of platinum complexes bearing combined triazole-amine or triazole-carboxylate moieties. Striking differences in the chelation modes are observed between the two series. One of the triazole-amine platinum complexes exhibits selective cytotoxicity against breast cancer cells lines. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).

引用

页码：298 / 305

页数：8

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