The coming-of-age of the hygiene hypothesis

被引：106

作者：

Martinez, FD ^{[1
]}

机构：

[1] Univ Arizona, Resp Sci Ctr, Tucson, AZ USA

来源：

RESPIRATORY RESEARCH | 2001年 / 2卷 / 03期

关键词：

atopy; CD14; endotoxin; genetics; hygiene;

D O I：

10.1186/rr48

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The hygiene hypothesis, as originally proposed, postulated an inverse relation between the incidence of infectious diseases in early life and the subsequent development of allergies and asthma. New evidence from epidemiological, biological and genetic studies has significantly enlarged the scope of the hypothesis. It now appears probable that environmental 'danger' signals regulate the pattern of immune responses in early life. Microbial burden in general, and not any single acute infectious illness, is the main source of these signals. The latter interact with a sensitive and complex receptor system, and genetic variations in this receptor system may be an important determinant of inherited susceptibility to asthma and allergies.

引用

页码：129 / 132

页数：4

共 29 条

[1]

AMELUNG PJ, 2000, AM J RESP CRIT CARE, V161, pA927

[2]

Braun-Fahrländer C, 1999, CLIN EXP ALLERGY, V29, P28, DOI 10.1046/j.1365-2222.1999.00479.x

[3]

CELEDON JC, 2000, AM J RESP CRIT CARE, V161, pA927

[4] Relative scarcity of asthma and atopy among rural adolescents raised on a farm [J].