Apoptosis and T-cell depletion during feline infectious peritonitis

被引:69
作者
Haagmans, BL
Egberink, HF
Horzinek, MC
机构
关键词
D O I
10.1128/JVI.70.12.8977-8983.1996
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Cats that have succumbed to feline infectious peritonitis, an immune-mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs. The ascitic fluid that develops in the course of the condition causes apoptosis in vitro but only in activated T cells. Since feline infectious peritonitis virus does not infect T cells, and viral proteins did not inhibit T-cell proliferation, we postulate that soluble mediators released during the infection cause apoptosis and T-cell depletion.
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页码:8977 / 8983
页数:7
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