Potent inhibitors of the hedgehog signaling pathway

被引：42

作者：

Brunton, Shirley A. ^{[1
]}

Stibbard, John H. A. ^{[1
]}

Rubin, Lee L. ^{[2
]}

Kruse, Lawrence I. ^{[2
]}

Guicherit, Oivin M. ^{[2
]}

Boyd, Edward A. ^{[1
]}

Price, Steven ^{[1
]}

机构：

[1] Evotec, Abingdon OX14 4RX, Oxon, England

[2] Curis Inc, Cambridge, MA 02138 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 05期

关键词：

D O I：

10.1021/jm070694n

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.

引用

页码：1108 / 1110

页数：3

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