Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study

被引：379

作者：

Bonaz, B. ^{[1
,2
]}

Sinniger, V. ^{[1
,2
]}

Hoffmann, D. ^{[3
]}

Clarencon, D. ^{[2
]}

Mathieu, N. ^{[1
]}

Dantzer, C. ^{[4
]}

Vercueil, L. ^{[5
]}

Picq, C. ^{[2
]}

Trocme, C. ^{[6
]}

Faure, P. ^{[7
]}

Cracowski, J-L. ^{[8
]}

Pellissier, S. ^{[2
]}

机构：

[1] Univ Hosp, Univ Clin Hepatogastroenterol, Grenoble, France

[2] Univ Grenoble Alpes, Inst Neurosci, INSERM, Stress & Neurodigest Interact,U1216, Grenoble, France

[3] Univ Hosp, Dept Neurosurg, Grenoble, France

[4] Savoie Univ, Dept Psychol, LIP, PC2S, Chambery, France

[5] Univ Hosp, Dept Neurol, Grenoble, France

[6] Univ Hosp, Inst Biol & Pathol, Lab Prot & Enzyme Biochem, Grenoble, France

[7] Univ Hosp, Inst Biol & Pathol, INSERM, U1042,HP2, Grenoble, France

[8] Univ Hosp, Dept Clin Pharmacol, INSERM, CIC1406, Grenoble, France

来源：

NEUROGASTROENTEROLOGY AND MOTILITY | 2016年 / 28卷 / 06期

关键词：

cholinergic anti-inflammatory pathway; Crohn's disease; heart rate variability; vagus nerve; vagus nerve stimulation; IMPACT; GUT;

D O I：

10.1111/nmo.12792

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The vagus nerve (VN) is a link between the brain and the gut. The VN is a mixed nerve with anti-inflammatory properties through the activation of the hypothalamic-pituitary-adrenal axis by its afferents and by activating the cholinergic anti-inflammatory pathway through its efferents. We have previously shown that VN stimulation (VNS) improves colitis in rats and that the vagal tone is blunted in Crohn's disease (CD) patients. We thus performed a pilot study of chronic VNS in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical remission and a secondary endpoint to induce biological (CRP and/or fecal calprotectin) and endoscopic remission and to restore vagal tone (heart rate variability). Vagus nerve stimulation was feasible and well-tolerated in all patients. Among the seven patients, two were removed from the study at 3 months for clinical worsening and five evolved toward clinical, biological, and endoscopic remission with a restored vagal tone. These results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD.

引用

页码：948 / 953

页数：6

共 22 条

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