Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: Protective effects of SkQ1, lithium ions and insulin

被引：50

作者：

Plotnikov, E. Y. ^{[1
,2
]}

Vasileva, A. K. ^{[1
,2
]}

Arkhangelskaya, A. A. ^{[1
]}

Pevzner, I. B. ^{[3
]}

Skulachev, V. P. ^{[1
]}

Zorov, D. B. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Ctr Mitoengn, Moscow 119991, Russia

[3] Inst Transplantol & Artificial Organs, Moscow, Russia

来源：

FEBS LETTERS | 2008年 / 582卷 / 20期

关键词：

mitochondria; fission; fusion; apoptosis; ischemia/reoxygenation;

D O I：

10.1016/j.febslet.2008.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenyl-phosphonium (SkQ1) as well as insulin and the inhibitor of glycogen-synthase kinase, Li+ are shown to (i) protect renal tubular cells from an apoptotic death and (ii) diminish mitochondrial fission ( the thread-grain transition) induced by ischemia/reoxygenation. However, SkQ1 and LiCl protected the mitochondrial reticulum of skin. broblasts from ultraviolet-induced fission but were ineffective in preventing a further cell death. This means that mitochondrial fission is not essential for apoptotic cascade progression. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3117 / 3124

页数：8

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