Inhibition of calmodulin-dependent Calcium-ATPase and phosphodiesterase by various cyclopeptides and peptide alkaloids from the Zizyphus species

被引：21

作者：

Hwang, KH

Han, YN ^{[1
]}

Han, BH

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

[2] Konkuk Univ, Inst Hlth & Nutr, Seoul 143701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 03期

关键词：

Zizyphus vulgaris var. spinosus; Zizyphus jujuba var. inermis; cyclopeptide alkaloid; Ca2+-ATPase; phosphodiesterase; calmodulin;

D O I：

10.1007/BF02978257

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects of various sedative cyclopeptides and peptide alkaloids from the Zizyphus species on calmodulin-dependent Ca2+-ATPase and phosphodiesterase were investigated. Calmodulin-induced activation of Ca2+-ATPase was strongly inhibited by sanjoinine-A dialdehyde (IC50, 2.3 muM), -Ah1 (IC50, 4.0 muM), -A (IC50, 4.6 muM), and -G2 (IC50, 7.2 muM), while calmodulin-induced activation of phosphodiesterase was strongly inhibited by both deachuine-S10 (IC50, 4.9 muM) and sanjoinine-D (IC50, 9.0 muM). The inhibitory activity of the various cyclopeptides and peptide alkaloids on Ca2+-ATPase was found to correlate well with their sedative activity.

引用

页码：202 / 206

页数：5

共 28 条

[1]

GIETZEN K, 1980, BIOCHEM BIOPH RES CO, V94, P674, DOI 10.1016/0006-291X(80)91285-1

[2]

HAN B H, 1987, Archives of Pharmacal Research (Seoul), V10, P203, DOI 10.1007/BF02857740

[3]

HAN B H, 1987, Archives of Pharmacal Research (Seoul), V10, P208, DOI 10.1007/BF02857741

[4]

Han B. H., 1985, Kor. J. Pharmacogn., V16, P233