Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces

被引：201

作者：

Chen, Li ^{[2
,3
]}

Liu, Xueli ^{[2
,3
]}

Su, Bin ^{[2
]}

Li, Jing ^{[1
,3
]}

Jiang, Lei ^{[2
]}

Han, Dong ^{[1
]}

Wang, Shutao ^{[2
]}

机构：

[1] Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Chem, BNLMS, Beijing, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 38期

关键词：

IMMUNODEFICIENCY-VIRUS-INFECTION; CIRCULATING TUMOR-CELLS; SILICON NANOWIRE ARRAYS; HIV-INFECTION; MICROARRAYS; ADHESION; ENUMERATION; GENERATION; ENRICHMENT; NANOSCALE;

D O I：

10.1002/adma.201102435

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A nanostructured platform that combines silicon nanowire arrays and DNA aptamers realizes significant capture and efficient release of T lymphocytes. An approximately two orders of magnitude enhancement in capture efficiency compared to planar surfaces is observed with good release performance. This method of capture and release provides an artful strategy to fulfill the demands of cell isolation and diagnosis.

引用

收藏

页码：4376 / +

页数：6

相关论文

共 49 条

[1]

Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor [J].

Adams, Andre A. ;

Okagbare, Paul I. ;

Feng, Juan ;

Hupert, Matuesz L. ;

Patterson, Don ;

Goettert, Jost ;

McCarley, Robin L. ;

Nikitopoulos, Dimitris ;

Murphy, Michael C. ;

Soper, Steven A. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (27) :8633-8641

[2]

Cell microarrays [J].

Angres, B .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2005, 5 (05) :769-779

[3]

Capture of antigen-specific T lymphocytes from human blood by selective immortalization to establish long-term T-cell lines maintaining primary cell characteristics [J].

Barsov, Eugene V. ;

Andersen, Hanne ;

Coalter, Vicky J. ;

Carrington, Mary ;

Lifson, Jeffrey D. ;

Ott, David E. .

IMMUNOLOGY LETTERS, 2006, 105 (01) :26-37

[4]

Belov L, 2001, CANCER RES, V61, P4483

[5]

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function [J].

Bettinger, Christopher J. ;

Langer, Robert ;

Borenstein, Jeffrey T. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (30) :5406-5415

[6]

An Electrochemical Sensor for the Detection of Protein-Small Molecule Interactions Directly in Serum and Other Complex Matrices [J].

Cash, Kevin J. ;

Ricci, Francesco ;

Plaxco, Kevin W. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (20) :6955-+

[7]

Marked differences in human melanoma antigen-specific T cell responsiveness after vaccination using a functional microarray [J].

Chen, DS ;

Soen, Y ;

Stuge, TB ;

Lee, PP ;

Weber, JS ;

Brown, PO ;

Davis, MM .

PLOS MEDICINE, 2005, 2 (10) :1018-1030

[8]

On improving blood compatibility: From bioinspired to synthetic design and fabrication of biointerfacial topography at micro/nano scales [J].

Chen, Li ;

Han, Dong ;

Jiang, Lei .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 85 (01) :2-7

[9]

Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography [J].

Chen, Li ;

Liu, Mingjie ;

Bai, Hao ;

Chen, Peipei ;

Xia, Fan ;

Han, Dong ;

Jiang, Lei .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (30) :10467-10472

[10]

Peptide and small molecule microarray for high throughput cell adhesion and functional assays [J].

Falsey, JR ;

Renil, M ;

Park, S ;

Li, SJ ;

Lam, KS .

BIOCONJUGATE CHEMISTRY, 2001, 12 (03) :346-353

← 1 2 3 4 5 →