Dendritic cell aggresome-like-induced structure formation and delayed antigen presentation coincide in influenza virus-infected dendritic cells

被引:40
作者
Herter, S
Osterloh, P
Hilf, N
Rechtsteiner, G
Höhfeld, J
Rammensee, HG
Schild, H
机构
[1] Univ Mainz, Inst Immunol, D-55131 Mainz, Germany
[2] Univ Tubingen, Dept Immunol, Inst Cell Biol, Tubingen, Germany
[3] Univ Bonn, Inst Cell Biol, D-5300 Bonn, Germany
关键词
D O I
10.4049/jimmunol.175.2.891
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Influenza virus infection induces maturation of murine dendritic cells (DCs), which is most important for the initiation of an immune response. However, in contrast to EL-4 and MC57 cells, DCs present viral CTL epitopes with a delay of up to 10 h. This delay in Ag presentation coincides with the up-regulation of MHC class I molecules as well as costimulatory molecules on the cell surface and the accumulation of newly synthesized ubiquitinated proteins in large cytosolic structures, called DC aggresome-like-induced structures (DALIS). These structures were observed previously after LPS-induced maturation of DCs, and it was speculated that they play a role in the regulation of MHC class I Ag presentation. Our findings provide the first evidence for a connection between DC maturation, MHC class I-restricted Ag presentation, and DALIS formation, which is further supported by the observation that DALIS contain ubiquitinated influenza nucleoprotein.
引用
收藏
页码:891 / 898
页数:8
相关论文
共 34 条
[1]   Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].
Albert, ML ;
Sauter, B ;
Bhardwaj, N .
NATURE, 1998, 392 (6671) :86-89
[2]   Intracellular localization of proteasomal degradation of a viral antigen [J].
Antón, LC ;
Schubert, U ;
Bacík, I ;
Princiotta, MF ;
Wearsch, PA ;
Gibbs, J ;
Day, PM ;
Realini, C ;
Rechsteiner, MC ;
Bennink, JR ;
Yewdell, JW .
JOURNAL OF CELL BIOLOGY, 1999, 146 (01) :113-124
[3]   Immunobiology of dendritic cells [J].
Banchereau, J ;
Briere, F ;
Caux, C ;
Davoust, J ;
Lebecque, S ;
Liu, YT ;
Pulendran, B ;
Palucka, K .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+
[4]   Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[5]  
Camporeale A, 2003, CANCER RES, V63, P3688
[6]   Cutting edge: Microbial products elicit formation of dendritic cell aggresome-like induced structures in macrophages [J].
Canadien, V ;
Tan, T ;
Zilber, R ;
Szeto, J ;
Perrin, AJ ;
Brumell, JH .
JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2471-2475
[7]   Maturation, activation, and protection of dendritic cells induced by double-stranded RNA [J].
Cella, M ;
Salio, M ;
Sakakibara, Y ;
Langen, H ;
Julkunen, I ;
Lanzavecchia, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :821-829
[8]   Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections [J].
Crowe, SR ;
Turner, SJ ;
Miller, SC ;
Roberts, AD ;
Rappolo, RA ;
Doherty, PC ;
Ely, KH ;
Woodland, DL .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (03) :399-410
[9]   Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation [J].
Delamarre, L ;
Holcombe, H ;
Mellman, I .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) :111-122
[10]   Control of cross-presentation during dendritic cell maturation [J].
Gil-Torregrosa, BC ;
Lennon-Duménil, AM ;
Kessler, B ;
Guermonprez, P ;
Ploegh, HL ;
Fruci, D ;
Van Endert, P ;
Amigorena, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (02) :398-407