The sevoflurane-sparing effect of nitrous oxide: a clinical study

被引：29

作者：

Jakobsson, J

Heidvall, M

Davidson, S

机构：

[1] M&M Med Inc, Sabbatsberg Narsjukhuset, Dept Anaesthesia & Orthopaed Surg, Stockholm, Sweden

[2] Danderyd Hosp, Dept Anaesthesia, Stockholm, Sweden

来源：

ACTA ANAESTHESIOLOGICA SCANDINAVICA | 1999年 / 43卷 / 04期

关键词：

general anesthesia; outpatients; sevoflurane; nitrous oxide; recovery; pain; nausea; discharge; anesthesia; cost;

D O I：

10.1034/j.1399-6576.1999.430408.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Background: We studied the sevoflurane-sparing effect of nitrous oxide in a prospective randomised study. Methods: Forty-two ASA I-II patients scheduled for elective knee arthroscopy under general anaesthesia were randomly assigned to a fresh gas flow consisting of oxygen in air or oxygen in nitrous oxide 1:2. All patients received a standardised anaesthesia consisting of induction with fentanyl and propofol and maintenance with sevoflurane adjusted according to clinical signs. The sevoflurane consumption was studied by means of weighing the vaporiser before and after every anaesthesia. Results: The mean sevoflurane consumption was reduced from 0.62 to 0.25 g/min, a 60% reduction, by the use of oxygen in nitrous oxide 1:2 in the fresh gas flow. The emergence was faster for the patients receiving nitrous oxide. No major differences were observed during recovery. Conclusion: Nitrous oxide was found to be cost-effective for use during short ambulatory knee arthroscopy.

引用

页码：411 / 414

页数：4

共 11 条

[1] RETRACTED: Economic considerations of the use of new anesthetics: A comparison of propofol, sevoflurane, desflurane, and isoflurane (Retracted article. See vol. 131, 2020) [J].