Biodegradable comb polyesters: Part 1 - Synthesis, characterization and structural analysis of poly(lactide) and poly(lactide-co-glycolide) grafted onto water-soluble poly(vinyl alcohol) as backbone

被引：110

作者：

Breitenbach, A ^{[1
]}

Kissel, T ^{[1
]}

机构：

[1] Philipps Univ Marburg, Dept Pharmaceut & Biopharm, D-35037 Marburg, Germany

来源：

POLYMER | 1998年 / 39卷 / 14期

关键词：

synthesis; characterization; biodegradable comb polyesters;

D O I：

10.1016/S0032-3861(97)10077-5

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

To overcome discontinuous or polyphasic drug release rates of parenteral delivery systems (PDSs) for peptides and proteins, typical for linear polyesters, novel biodegradable brush-like poly(lactide) and poly(lactide-co-glycolide) (PLG) grafted onto water-soluble poly(vinyl alcohol) (PVA) as backbone were investigated. These polymers were synthesized by ring-opening melt polymerization using stannous octoate as catalyst. The branched PVA-PLGs were characterized by 1D- and 2D-n.m.r. spectroscopy and other methods, such as i.r., g.p.c., d.s.c. and static light scattering. The incorporation of the backbone and the comb structure was demonstrated by H-1- and C-13-n.m.r. spectra, as well as by light scattering studies. The physico-chemical properties, such as molecular composition and architecture, molecular weight, degree of crystallinity, melting point and glass transition point, could be systematically adjusted to the requirements of drug delivery. Therefore, this new class of biodegradable polymers has considerable potential as a PDS. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3261 / 3271

页数：11

共 31 条

[11]

KIM SH, 1993, MAKROMOL CHEM, V194, P3229

[12]

KIM SH, 1992, MAKROMOL CHEM, V193, P1623

[13]

Kim SH, 1996, POLYM-KOREA, V20, P528

[14] PARENTERAL DEPOT-SYSTEMS ON THE BASIS OF BIODEGRADABLE POLYESTERS [J].

KISSEL, T ;

BRICH, Z ;

BANTLE, S ;

LANCRANJAN, I ;

NIMMERFALL, F ;

VIT, P .

JOURNAL OF CONTROLLED RELEASE, 1991, 16 (1-2) :27-41

[15] Parenteral protein delivery systems using biodegradable polyesters of ABA block structure, containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethylene oxide) B blocks [J].

Kissel, T ;

Li, YX ;

Volland, C ;

Gorich, S ;

Koneberg, R .

JOURNAL OF CONTROLLED RELEASE, 1996, 39 (2-3) :315-326

[16] POLYLACTONES .31. SN(II)OCTOATE-INITIATED POLYMERIZATION OF L-LACTIDE - A MECHANISTIC STUDY [J].

KRICHELDORF, HR ;

KREISERSAUNDERS, I ;

BOETTCHER, C .

POLYMER, 1995, 36 (06) :1253-1259

[17]

LEWIS DH, 1990, BIODEGRADABLE POLYM, V1

[18] Synthesis, characterization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly(L-lactic acid) blocks [J].

Li, SM ;

Rashkov, I ;

Espartero, JL ;

Manolova, N ;

Vert, M .

MACROMOLECULES, 1996, 29 (01) :57-62

[19]

LI YX, 1993, J CONTROL RELEASE, V27, P247

[20]

LI YX, 1994, J CONTROL RELEASE, V32, P121

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