Oxidation and erythrocyte senescence

被引：218

作者：

Kiefer, CR ^{[1
]}

Snyder, LM ^{[1
]}

机构：

[1] UMASS Mem Med Ctr, Dept Hosp Labs Clin Pathol, Worcester, MA 01605 USA

来源：

CURRENT OPINION IN HEMATOLOGY | 2000年 / 7卷 / 02期

关键词：

D O I：

10.1097/00062752-200003000-00007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Direct macrophage recognition of an externalized phosphatidylserine signal on senescent erythrocytes is a process of erythrophagocytic clearance that is in line with the general clearance process of all other circulating cells that become apoptotic, Advances in deciphering this process suggest that oxidation of the erythrocyte's hemoglobin, the salient target of the free radicals encountered in the circulatory environment, may drive subsequent steps. The progressive accumulation of oxidized hemoglobin covalently bound to the membrane skeleton not only disrupts membrane organization but also threatens eventual phospholipid oxidation via a calcium-promoted quasi-lipoxygenase activity. The emergence on the cell surface of a threshold concentration of oxidized phospholipids, principally phosphatidylserine, signals recognition by the CD36 macrophage receptor. (C) 2000 Lippincott Williams & Wilkins, Inc.

引用

页码：113 / 116

页数：4

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