Highly enantioselective hydrogenation of α,β-unsaturated phosphonates with iridium-phosphinooxazoline complex:: synthesis of a phosphorus analogue of naproxen

被引：57

作者：

Goulioukina, NS

Dolgina, TM

Bondarenko, GN

Beletskaya, IP

Ilyin, MM

Davankov, VA

Pfaltz, A

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia

[3] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(03)00224-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of pharmaceutically interesting optically active 1-arylethylphosphonates, including a phosphorus analogue of naproxen, has been synthesized with ee 92-95% via asymmetric hydrogenation under mild conditions using [Ir(cod)(phosphine oxazoline)](+) [BArF](-) catalysts. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1397 / 1401

页数：5

共 19 条

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