Macrolide resistance in Peptostreptococcus spp. mediated by ermTR:: Possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes
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Reig, M
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Hosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, SpainHosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, Spain
Reig, M
[1
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Galan, JC
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Hosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, SpainHosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, Spain
Galan, JC
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Baquero, F
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Hosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, SpainHosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, Spain
Baquero, F
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Perez-Diaz, JC
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Hosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, SpainHosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, Spain
Perez-Diaz, JC
[1
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[1] Hosp Ramon y Cajal, Natl Inst Hlth INSALUD, Dept Microbiol, E-28034 Madrid, Spain
Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus to macrolide-susceptible S. pyogenes strains indicates that this resistance determinant may circulate among gram-positive aerobic and anaerobic species of the oropharyngeal bacterial flora.