Immunosuppressive and non-immunosuppressive immunophilin ligands improve H2O2-induced cell damage by increasing glutathione levels in NG108-15 cells

被引：49

作者：

Tanaka, K ^{[1
]}

Fujita, N ^{[1
]}

Yoshioka, M ^{[1
]}

Ogawa, N ^{[1
]}

机构：

[1] Okayama Univ, Sch Med, Dept Neurosci, Inst Mol & Cellular Med, Okayama 7008558, Japan

来源：

BRAIN RESEARCH | 2001年 / 889卷 / 1-2期

关键词：

hydrogen peroxide; immunophilin ligands; FK506; (GPI1046; glutathione; NG108-15; cell;

D O I：

10.1016/S0006-8993(00)02851-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the effects of FK506 and its non-immunosuppressive derivative, GPI1046, on H2O2-induced oxidative cell damage in NG 108-15 cells. Our results suggest that the protective properties of GPI1046 are equipment with those of FK506 and may be mediated by increased intracellular concentrations of glutathione (GSH). Thus, non-immunosuppressive immunophilin ligands such as GPI1046 might be potentially for neurodegenerative diseases, particularly since they do not have serious side effects such as immune deficiency. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：225 / 228

页数：4

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