Histone deacetylase inhibitors: Overview and perspectives

被引：931

作者：

Dokmanovic, Milos ^{[1
]}

Clarke, Cathy ^{[1
]}

Marks, Paul A. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

来源：

MOLECULAR CANCER RESEARCH | 2007年 / 5卷 / 10期

关键词：

D O I：

10.1158/1541-7786.MCR-07-0324

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a group of targeted anticancer agents. The first of these new HDACi, vorinostat (suberoylanilide hydroxamic acid), has received Food and Drug Administration approval for treating patients with cutaneous T-cell lymphoma. This review focuses on the activities of the 11 zinc-containing HDACs, their histone and nonhistone protein substrates, and the different pathways by which HDACi induce transformed cell death. A hypothesis is presented to explain the relative resistance of normal cells to HDACi-induced cell death.

引用

页码：981 / 989

页数：9

共 116 条

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