Early stage Alzheimer's disease disrupts encoding of contextual information

被引:5
作者
Rickert, EJ [1 ]
Duke, LW [1 ]
Putzke, JD [1 ]
Marson, DC [1 ]
Graham, K [1 ]
机构
[1] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA
关键词
D O I
10.1076/anec.5.1.73.20
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Two experiments examined whether impairments in recognition memory in early stage Alzheimer's disease (AD) were due to deficits in encoding contextual information. Normal elderly (NE) and patients diagnosed with mild stage AD learned one of two tasks. In Experiment 1 correct recognition memory required participants to remember not only what items they had experienced on a given trial but also when they had experienced them; Experiment 2 required that participants remember only what they had seen, not when they had seen it. Large recognition memory differences were found between the AD and NE groups in the experiment where time tagging was crucial for successful performance. An error analysis indicated that this was not due to the perseveration of previous learned responses. In Experiment 2, the only requisite for successful recognition was remembering what one had experienced; memory of the temporal record was not necessary for successful performance. In this instance, recognition memory for the NE and AD groups was identical. Taken together these results suggest that memory deficits found in early stage AD are partly due to impaired processing of contextual cues that provide crucial information about when events occur.
引用
收藏
页码:73 / 81
页数:9
相关论文
共 27 条
[1]  
[Anonymous], HUMAN MEMORY AMNESIA
[2]  
[Anonymous], 1988, HUMAN ORGANIC MEMORY
[3]   DEMENTIA AND WORKING MEMORY [J].
BADDELEY, A ;
LOGIE, R ;
BRESSI, S ;
DELLASALA, S ;
SPINNLER, H .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY, 1986, 38 (04) :603-618
[4]   THE 2-COMPONENT HYPOTHESIS OF MEMORY DEFICIT IN ALZHEIMERS-DISEASE [J].
BADDELEY, A ;
DELLASALA, S ;
SPINNLER, H .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1991, 13 (02) :372-380
[5]   USE OF TEMPORAL CONTEXT INFORMATION IN ALZHEIMERS-DISEASE [J].
BECKER, JT ;
WESS, J ;
HUNKIN, NM ;
PARKIN, AJ .
NEUROPSYCHOLOGIA, 1993, 31 (02) :137-143
[6]   LONGITUDINAL ANALYSIS OF A 2-COMPONENT MODEL OF THE MEMORY DEFICIT IN ALZHEIMERS-DISEASE [J].
BECKER, JT ;
BAJULAIYE, O ;
SMITH, C .
PSYCHOLOGICAL MEDICINE, 1992, 22 (02) :437-445
[7]   WORKING MEMORY AND SECONDARY MEMORY DEFICITS IN ALZHEIMERS-DISEASE [J].
BECKER, JT .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1988, 10 (06) :739-753
[8]   FORGETTING FROM LONG-TERM-MEMORY IN DEMENTIA AND PURE AMNESIA - ROLE OF TASK, DELAY OF ASSESSMENT AND ETIOLOGY OF CEREBRAL-DAMAGE [J].
CARLESIMO, GA ;
SABBADINI, M ;
FADDA, L ;
CALTAGIRONE, C .
CORTEX, 1995, 31 (02) :285-300
[9]   SOME ANALYSES OF VERBAL ENCODING DEFICIT OF ALCOHOLIC KORSAKOFF PATIENTS [J].
CERMAK, LS ;
BUTTERS, N ;
MOREINES, J .
BRAIN AND LANGUAGE, 1974, 1 (02) :141-150
[10]   AUTOMATIC AND EFFORTFUL PROCESSES IN MEMORY [J].
HASHER, L ;
ZACKS, RT .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL, 1979, 108 (03) :356-388