Interaction of malachite green with guanine-rich single-stranded DNA: preferential binding to a G-quadruplex

被引：103

作者：

Bhasikuttan, Achikanath C. ^{[1
]}

Mohanty, Jyotirmayee ^{[1
]}

Pal, Haridas ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Radiat & Photochem Div, Bombay 400085, Maharashtra, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 48期

关键词：

DNA; dyes/pigments; fluorescence; G-quadruplexes; oligonucleotides;

D O I：

10.1002/anie.200703251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bound to be better: The formation of a strong complex between the chromophoric dye malachite green (MG, in green) and the G-quadruplex structure (represented in black) of the guanine-rich single-strand oligomer sequence d(G2T)13G results in a 100-fold enhancement of the fluorescence yield of MG. The existence of an intra- or interstrand G-quadruplex structure depends on the oligomer concentration and the ionic strength of the solution. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9305 / 9307

页数：3

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