Bioconversion of compactin into pravastatin by Streptomyces sp.

被引:65
作者
Park, JW
Lee, JK
Kwon, TJ
Yi, DH
Kim, YJ
Moon, SH
Suh, HH
Kang, SM
Park, YI
机构
[1] Catholic Univ Korea, Div Biotechnol, Puchon 420743, Gyonggi Do, South Korea
[2] Youngjin Pharmaceut Co Ltd, Biotechnol Lab, Pyungtaek Si 451860, South Korea
[3] Konkuk Univ, Dept Microbial Engn, Seoul 133701, South Korea
[4] Chinju Natl Univ, Dept Environm Engn, Chinju 660758, South Korea
[5] Catholic Univ Korea, Collaborat Inst Sci & Technol, Puchon 420743, Gyonggi Do, South Korea
关键词
bioconversion; compactin; cytochrome P-450; pavastatin; Streptomyces sp;
D O I
10.1023/A:1026281914301
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l(-1) from 750 mg compactin l(-1) in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l(-1) and 1000 mg pravastatin l(-1), respectively, with the conversion rate of 10 mg l(-1) h(-1). Continuous feeding of compactin increased production of pravastatin to 15 mg l(-1) h(-1).
引用
收藏
页码:1827 / 1831
页数:5
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