Stu2p and XMAP215: turncoat microtubule-associated proteins?

被引：15

作者：

Popov, AV

Karsenti, E

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] CEA, INSERM, Unite 366, DRDCCS, F-38054 Grenoble 9, France

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 11期

关键词：

D O I：

10.1016/j.tcb.2003.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The dynamics of microtubule-based (MT) cytoskeletons are controlled by a variety of accessory proteins: microtubule-associated proteins (MAPs), which usually stabilize MTs, and microtubule-destabilizers. Two related MAPs, XMAP215 and Stu2p, are known to stabilize MTs. However, recent studies report that these proteins have a MT-destabilizing function as well. Here we discuss the implications of these reports.

引用

收藏

页码：547 / 550

页数：4

相关论文

共 22 条

[1] Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts [J].

Arnal, I ;

Karsenti, E ;

Hyman, AA .

JOURNAL OF CELL BIOLOGY, 2000, 149 (04) :767-774

[2]

Charrasse S, 1998, J CELL SCI, V111, P1371

[3] mini spindles:: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila [J].

Cullen, CF ;

Deák, P ;

Glover, DM ;

Ohkura, H .

JOURNAL OF CELL BIOLOGY, 1999, 146 (05) :1005-1018

[4] Spindle-kinetochore attachment requires the combined action of Kin I-like KIp5/6 and AIp14/Dis1-MAPs in fission yeast [J].

Garcia, MA ;

Koonrugsa, N ;

Toda, T .

EMBO JOURNAL, 2002, 21 (22) :6015-6024

[5] A MICROTUBULE-ASSOCIATED PROTEIN FROM XENOPUS EGGS THAT SPECIFICALLY PROMOTES ASSEMBLY AT THE PLUS-END [J].

GARD, DL ;

KIRSCHNER, MW .

JOURNAL OF CELL BIOLOGY, 1987, 105 (05) :2203-2215

[6]

Gräf R, 2000, J CELL SCI, V113, P1747

[7] XMAP215: a key component of the dynamic microtubule cytoskeleton [J].

Kinoshita, K ;

Habermann, B ;

Hyman, AA .

TRENDS IN CELL BIOLOGY, 2002, 12 (06) :267-273

[8] Reconstitution of physiological microtubule dynamics using purified components [J].

Kinoshita, K ;

Arnal, I ;

Desai, A ;

Drechsel, DN ;

Hyman, AA .

SCIENCE, 2001, 294 (5545) :1340-1343

[9] Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast [J].

Kosco, KA ;

Pearson, CG ;

Maddox, PS ;

Wang, PJJ ;

Adams, IR ;

Salmon, ED ;

Bloom, K ;

Huffaker, TC .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (09) :2870-2880

[10]

Ohkura H, 2001, J CELL SCI, V114, P3805