Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

被引：4

作者：

Isbil-Buyukcoskun, N ^{[1
]}

Gulec, G

Ozluk, K

Ulus, IH

机构：

[1] Uludag Univ, Fac Med, Dept Physiol, TR-16059 Corukle, Bursa, Turkey

[2] Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Corukle, Bursa, Turkey

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 2001年 / 34卷 / 06期

关键词：

choline; captopril; intracerebroventricular choline; blood pressure;

D O I：

10.1590/S0100-879X2001000600018

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 mug) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin: system blockade on blood pressure increase induced by choline (150 mug, icy), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 mug, icy), was administered 3 min before choline. Twenty-five mug captopril did not block the presser effect of choline, while 50 mug captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icy choline in normotensive rats.

引用

页码：815 / 820

页数：6

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