Mutation in the DNA gyrase A gene of Escherichia coli that expands the quinolone resistance-determining region

被引：84

作者：

Friedman, SM

Lu, T

Drlica, K

机构：

[1] CUNY Hunter Coll, Dept Biol Sci, New York, NY 10021 USA

[2] Publ Hlth Res Inst, New York, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 08期

关键词：

D O I：

10.1128/AAC.45.8.2378-2380.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.

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页码：2378 / 2380

页数：3

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