Induction of Psychosis by Δ9-Tetrahydrocannabinol Reflects Modulation of Prefrontal and Striatal Function During Attentional Salience Processing

被引：177

作者：

Bhattacharyya, Sagnik ^{[1
]}

Crippa, Jose Alexandre ^{[4
]}

Allen, Paul ^{[1
]}

Martin-Santos, Rocio ^{[1
,5
]}

Borgwardt, Stefan ^{[1
,6
]}

Fusar-Poli, Paolo ^{[1
]}

Rubia, Katya ^{[2
]}

Kambeitz, Joseph ^{[1
]}

O'Carroll, Colin ^{[7
]}

Seal, Marc L. ^{[8
]}

Giampietro, Vincent ^{[3
]}

Brammer, Michael ^{[3
]}

Zuardi, Antonio Waldo ^{[4
]}

Atakan, Zerrin ^{[1
]}

McGuire, Philip K. ^{[1
]}

机构：

[1] Kings Coll London, Dept Psychosis Studies, Inst Psychiat, London SE5 8AF, England

[2] Kings Coll London, Dept Child & Adolescent Psychiat, Inst Psychiat, London SE5 8AF, England

[3] Kings Coll London, Dept Neuroimaging, Inst Psychiat, London SE5 8AF, England

[4] Univ Sao Paulo, Dept Neurol Psychiat & Med Psychol, Fac Med Ribeirao Preto, Sao Paulo, Brazil

[5] Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Inst Neurosci, Psychiat Dept,Hosp Clin, Barcelona, Spain

[6] Univ Basel, Psychiat Outpatient Dept, Basel, Switzerland

[7] Dart Neurosci LLC, San Diego, CA USA

[8] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

来源：

ARCHIVES OF GENERAL PSYCHIATRY | 2012年 / 69卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

ACUTE ORAL DELTA(9)-TETRAHYDROCANNABINOL; CEREBRAL-BLOOD-FLOW; CANNABIS USE; REINFORCING EFFICACY; REWARD PREDICTION; ABERRANT SALIENCE; HUMAN HIPPOCAMPAL; LINKING BIOLOGY; ACUTE MARIJUANA; SCHIZOPHRENIA;

D O I：

10.1001/archgenpsychiatry.2011.161

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Context: The aberrant processing of salience is thought to be a fundamental factor underlying psychosis. Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing. Objective: To examine the effects of Delta 9-tetrahydrocannabinol (Delta 9-THC) and cannabidiol (CBD) on regional brain function during salience processing. Design: Volunteers were studied using event-related functional magnetic resonance imaging on 3 occasions after administration of Delta 9-THC, CBD, or placebo while performing a visual oddball detection paradigm that involved allocation of attention to infrequent (oddball) stimuli within a string of frequent (standard) stimuli. Setting: University center. Participants: Fifteen healthy men with minimal previous cannabis use. Main Outcome Measures: Symptom ratings, task performance, and regional brain activation. Results: During the processing of oddball stimuli, relative to placebo, Delta 9-THC attenuated activation in the right caudate but augmented it in the right prefrontal cortex. Delta 9-Tetrahydrocannabinol also reduced the response latency to standard relative to oddball stimuli. The effect of Delta 9-THC in the right caudate was negatively correlated with the severity of the psychotic symptoms it induced and its effect on response latency. The effects of CBD on task-related activation were in the opposite direction of those of Delta 9-THC; relative to placebo, CBD augmented left caudate and hippocampal activation but attenuated right prefrontal activation. Conclusions: Delta 9-Tetrahydrocannabinol and CBD differentially modulate prefrontal, striatal, and hippocampal function during attentional salience processing. These effects may contribute to the effects of cannabis on psychotic symptoms and on the risk of psychotic disorders.

引用

页码：27 / 36

页数：10

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