Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells

被引：11

作者：

Gribben, Lujia ^{[1
]}

Baxter, Robert C. ^{[1
]}

Marsh, Deborah J. ^{[1
]}

机构：

[1] Univ Sydney, Royal N Shore Hosp, Hormones & Canc Div, Kolling Inst Med Res, St Leonards, NSW 2065, Australia

来源：

CANCER LETTERS | 2012年 / 317卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

Endometrial cancer; IGFBP-3; PTEN; Migration; RETINOID-X-RECEPTOR; FACTOR-I; POSTMENOPAUSAL WOMEN; FACTOR BINDING-PROTEIN-3; SIGNALING PATHWAYS; PROSTATE-CANCER; SERUM-LEVELS; BARBED END; CARCINOMA; IGFBP-3;

D O I：

10.1016/j.canlet.2011.11.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of migration-associated markers at the leading edge of cell membranes. Opposite effects were seen with either the addition of recombinant IGFBP-3 or overexpression of IGEBP-3. Cells with mutated PTEN had the highest IGFBP-3 expression and the slowest migration rates. This study demonstrates that endogenous IGEBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 48

页数：8

共 54 条

[1]

[Anonymous], CA CANC J CLIN

[2]

Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer [J].