Bariatric surgery in a patient with complete MC4R deficiency

被引：48

作者：

Aslan, I. R. ^{[3
]}

Ranadive, S. A. ^{[4
]}

Ersoy, B. A. ^{[1
,2
]}

Rogers, S. J. ^{[5
]}

Lustig, R. H. ^{[3
]}

Vaisse, C. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA

[4] Childrens Hosp & Res Ctr Oakland, Dept Endocrinol, Oakland, CA USA

[5] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2011年 / 35卷 / 03期

关键词：

melanocortin-4; receptor; adolescent; gastric banding; vagotomy; bariatric surgery; HOMOZYGOUS NULL MUTATION; MELANOCORTIN-4; RECEPTOR; HYPOTHALAMIC OBESITY; MORBID-OBESITY; CRANIOPHARYNGIOMA; ADOLESCENTS; SYSTEM; ASSOCIATION; ADULTS; GENE;

D O I：

10.1038/ijo.2010.168

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Bariatric surgery is often successful for treatment of severe obesity. The mechanisms of weight loss after bariatric surgery and the role of central energy homeostatic pathways in this weight loss process are not well understood. The study of individuals with complete loss of function of genes important in the leptin-melanocortin system may help establish the significance of these pathways for weight loss after bariatric surgery. We describe the outcome of bariatric surgery in an adolescent with compound heterozygosity and complete functional loss of both alleles of the melanocortin 4 receptor (MC4R). The patient underwent laparoscopic adjustable gastric banding and truncal vagotomy at 18 8/12 years of age, which resulted in initial, but not long-term weight loss. Our experience with this patient suggests that complete MC4R deficiency impairs response to gastric banding and results in poor weight loss after this surgery. International Journal of Obesity (2011) 35, 457-461; doi:10.1038/ijo.2010.168; published online 24 August 2010

引用

页码：457 / 461

页数：5

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