Transforming growth factor-β signaling and ubiquitinators in cancer

被引：47

作者：

Glasgow, Eric ^{[1
]}

Mishra, Lopa ^{[1
,2
]}

机构：

[1] Georgetown Univ, Med Ctr, Med & Lombardi Canc Ctr, Lab Canc Genet Digest Dis & GI Dev Biol,Dept Surg, Washington, DC 20007 USA

[2] Vet Affairs Med Ctr, Washington, DC 20422 USA

来源：

关键词：

D O I：

10.1677/ERC-07-0168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Transforming growth factor-beta (TGF-beta) represents a large family of growth and differentiation factors that mobilize complex signaling networks to regulate cellular differentiation, proliferation, motility, adhesion, and apoptosis. TGF-beta signaling is tightly regulated by multiple complex mechanisms, and its deregulation plays a key role in the progression of many forms of cancer. Upon ligand binding, TGF-beta signals are transduced by Smad proteins, which in turn are tightly dependent on modulation by adaptor proteins such as embryonic liver fodrin, Smad anchor for receptor activation, filamin, and crkl. A further layer of regulation is imposed by ubiquitin-mediated targeting and proteasomal degradation of specific components of the TGF-beta signaling pathway. This review focuses on the ubiquitinators that regulate TGF-beta signaling and the association of these ubiquitin ligases with various forms of cancer. Delineating the role of ubiquitinators in the TGF-beta signaling pathway could yield powerful novel therapeutic targets for designing new cancer treatments.

引用

页码：59 / 72

页数：14

共 127 条

[1]

T beta RI phosphorylation of Smad2 on Ser(465) and Ser(467) is required for Smad2-Smad4 complex formation and signaling [J].