An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression

被引：6

作者：

Jun, G ^{[1
]}

Song, Y ^{[1
]}

Stein, CM ^{[1
]}

Iyengar, SK ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

来源：

BMC GENETICS | 2003年 / 4卷 / Suppl 1期

关键词：

D O I：

10.1186/1471-2156-4-S1-S8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genome-wide screen was conducted for type 2 diabetes progression genes using measures of elevated fasting glucose levels as quantitative traits from the offspring enrolled in the Framingham Heart Study. We analyzed young ( 20 - 34 years) and old (greater than or equal to 35 years) subjects separately, using single-point and multipoint sibpair analysis, because of the possible differential impact of progression on the groups of interest. We observed significant linkage with change in fasting glucose levels on 1q25-32 ( p = 5.21 x 10(-8)), 3p26.3- 21.31 ( p = 1 x 10(-11)), 8q23.1- 24.13 ( p = 2.94 x 10(-6)), 9p24.1- 21.3 ( p = 7 x 10(-7)), and 18p11.31- q22.1 ( p < 10(-11)). The evidence for linkage on chromosomes 8 and 18 was consistent for the subset of study participants aged 43 through 55 years.

引用

页数：7

共 17 条

[1] Diabetes mellitus and genetically programmed defects in β-cell function [J].

Bell, GI ;

Polonsky, KS .

NATURE, 2001, 414 (6865) :788-791

[2]

Elston RC, 2000, GENET EPIDEMIOL, V19, P1, DOI 10.1002/1098-2272(200007)19:1<1::AID-GEPI1>3.0.CO

[3]

2-E

[4] The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) study.: I.: An autosomal genome scan for genes that predispose to type 2 diabetes [J].

Ghosh, S ;

Watanabe, RM ;

Valle, TT ;

Hauser, ER ;

Magnuson, VL ;

Langefeld, CD ;

Ally, DS ;

Mohlke, KL ;

Silander, K ;

Kohtamäki, K ;

Chines, P ;

Balow, J ;

Birznieks, G ;

Chang, J ;

Eldridge, W ;

Erdos, MR ;

Karanjawala, ZE ;

Knapp, JI ;

Kudelko, K ;

Martin, C ;

Morales-Mena, A ;

Musick, A ;

Musick, T ;

Pfahl, C ;

Porter, R ;

Rayman, JB ;

Rha, D ;

Segal, L ;

Shapiro, S ;

Sharaf, R ;

Shurtleff, B ;

So, A ;

Tannenbaum, J ;

Te, C ;

Tovar, J ;

Unni, A ;

Welch, C ;

Whiten, R ;

Witt, A ;

Blaschak-Harvan, J ;

Douglas, JA ;

Duren, WL ;

Epstein, MP ;

Fingerlin, TE ;

Kaleta, HS ;

Lange, EM ;

Li, C ;

McEachin, RC ;

Stringham, HM ;

Trager, E .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (05) :1174-1185

[5] INVESTIGATION OF LINKAGE BETWEEN A QUANTITATIVE TRAIT AND A MARKER LOCUS [J].

HASEMAN, JK ;

ELSTON, RC .

BEHAVIOR GENETICS, 1972, 2 (01) :3-19

[6]

Hayden Melvin R, 2002, JOP, V3, P126

[7] Clinical review 135 -: The importance of β-cell failure in the development and progression of type 2 diabetes [J].

Kahn, SE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) :4047-4058

[8] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS [J].

LANDER, E ;

KRUGLYAK, L .

NATURE GENETICS, 1995, 11 (03) :241-247

[9] Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families:: The Botnia study [J].

Lindgren, CM ;

Mahtani, MM ;

Widén, E ;

McCarthy, MI ;

Daly, MJ ;

Kirby, A ;

Reeve, MP ;

Kruglyak, L ;

Parker, A ;

Meyer, J ;

Almgren, P ;

Lehto, M ;

Kanninen, T ;

Tuomi, T ;

Groop, LC ;

Lander, ES .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (02) :509-516

[10] A genome-wide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees -: The Framingham Offspring Study [J].

Meigs, JB ;

Panhuysen, CIM ;

Myers, RH ;

Wilson, PWF ;

Cupples, LA .

DIABETES, 2002, 51 (03) :833-840

← 1 2 →