No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy

被引：20

作者：

Brodtkorb, E

Nakken, KO

Steinlein, OK ^{[1
]}

机构：

[1] St Olavs Hosp, Dept Neurol, Trondheim, Norway

[2] Natl Ctr Epilepsy, Sandvika, Norway

[3] Univ Hosp Bonn, Inst Human Genet, D-53111 Bonn, Germany

来源：

EPILEPSY RESEARCH | 2003年 / 56卷 / 2-3期

关键词：

epilepsy; ADLTE; LGI1; tumor suppressor gene;

D O I：

10.1016/j.eplepsyres.2003.09.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Leucine-rich Glioma Inactivated-1 (LGI1) gene is supposed to be a tumor suppressor gene involved in glial tumors. Mutations in this gene were recently found to cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). We have now analysed the comorbidity in a large Norwegian ADLTE family. No evidence was found that LGI1 is a high-penetrance tumor suppressor gene associated with a serious risk for malignancies in ADLTE families. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：205 / 208

页数：4

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