GABA Is Depolarizing in Hippocampal Dentate Granule Cells of the Adolescent and Adult Rats

被引：49

作者：

Chiang, Po-Han ^{[1
,2
]}

Wu, Pu-Yeh ^{[1
,2
]}

Kuo, Tzu-Wei ^{[1
,2
]}

Liu, Yu-Chao ^{[1
,2
]}

Chan, Chu-Fang ^{[1
,2
]}

Chien, Ta-Chun ^{[3
,4
]}

Cheng, Jen-Kun ^{[5
,6
,7
]}

Huang, Yu-Yin ^{[8
]}

Chiu, Cheng-Di ^{[9
]}

Lien, Cheng-Chang ^{[1
,2
]}

机构：

[1] Natl Yang Ming Univ, Inst Neurosci, Sch Life Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Brain Res Ctr, Sch Life Sci, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Sch Life Sci, Taipei 112, Taiwan

[4] Acad Sinica, Inst Biomed Sci, Taiwan Int Grad Program, Program Mol Med, Taipei 115, Taiwan

[5] Mackay Mem Hosp, Dept Anesthesiol, Taipei 104, Taiwan

[6] Mackay Med Nursing & Management Coll, Taipei 112, Taiwan

[7] Taipei Med Univ, Dept Anesthesiol, Taipei 110, Taiwan

[8] Cheng Hsin Gen Hosp, Dept Anesthesiol, Taipei 112, Taiwan

[9] China Med Univ Hosp, Dept Neurosurg, Taichung 404, Taiwan

来源：

JOURNAL OF NEUROSCIENCE | 2012年 / 32卷 / 01期

关键词：

SYNCHRONIZED GAMMA-OSCILLATIONS; INTERNEURON NETWORKS; COTRANSPORTER KCC2; EXCITATORY ACTIONS; GYRUS; NEUROGENESIS; CONDUCTANCE; INTEGRATION; INHIBITION; POTENTIALS;

D O I：

10.1523/JNEUROSCI.3393-11.2012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

GABAergic signaling in hippocampal pyramidal neurons undergoes a switch from depolarizing to hyperpolarizing during early neuronal development. Whether such a transformation of GABAergic action occurs in dentate granule cells (DGCs), located at the first stage of the hippocampal trisynaptic circuit, is unclear. Here, we use noninvasive extracellular recording to monitor the effect of synaptically released GABA on the DGC population. We find that GABAergic responses in adolescent and adult rat DGCs are still depolarizing from rest. Using a morphologically realistic DGC model, we show that GABAergic action, depending on its precise timing and location, can have either an excitatory or inhibitory role in signal processing in the dentate gyrus.

引用

页码：62 / 67

页数：6

共 28 条

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