Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

被引：1661

作者：

Postow, Michael A. ^{[7
]}

Callahan, Margaret K. ^{[7
]}

Barker, Christopher A. ^{[2
,7
]}

Yamada, Yoshiya ^{[7
]}

Yuan, Jianda ^{[2
,3
]}

Kitano, Shigehisa ^{[3
]}

Mu, Zhenyu ^{[3
]}

Rasalan, Teresa ^{[3
]}

Adamow, Matthew ^{[3
]}

Ritter, Erika ^{[5
]}

Sedrak, Christine ^{[5
]}

Jungbluth, Achim A. ^{[5
]}

Chua, Ramon ^{[5
]}

Yang, Arvin S. ^{[8
]}

Roman, Ruth-Ann ^{[4
]}

Rosner, Samuel ^{[6
]}

Benson, Brenna ^{[9
]}

Allison, James P. ^{[3
,7
,10
]}

Lesokhin, Alexander M. ^{[7
]}

Gnjatic, Sacha ^{[5
]}

Wolchok, Jedd D. ^{[1
,3
,5
,7
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Melanoma & Sarcoma Serv, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, Program Immunol, New York, NY 10065 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Nursing, New York, NY 10065 USA

[5] Ludwig Inst Canc Res, New York Branch, New York, NY USA

[6] SUNY Stony Brook, Stony Brook, NY 11794 USA

[7] Weill Cornell Med Coll, New York, NY USA

[8] Bristol Myers Squibb Co, Princeton, NJ USA

[9] Colorado State Univ, Ft Collins, CO 80523 USA

[10] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2012年 / 366卷 / 10期

基金：

美国国家卫生研究院;

关键词：

RENAL-CELL CARCINOMA; MALIGNANT-MELANOMA; CTLA-4; BLOCKADE; CANCER-PATIENTS; LUNG-CANCER; RADIATION; ANTIBODY; RESPONSES; NY-ESO-1; RADIOTHERAPY;

D O I：

10.1056/NEJMoa1112824

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancertestis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.)

引用

页码：925 / 931

页数：7

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