100 years of Rous sarcoma virus

被引：90

作者：

Weiss, Robin A. ^{[1
]}

Vogt, Peter K. ^{[2
]}

机构：

[1] UCL, Div Infect & Immun, London WC1E 6BT, England

[2] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2011年 / 208卷 / 12期

关键词：

DEPENDENT DNA POLYMERASE; SV40-TRANSFORMED CELLS; T-ANTIGEN; RETROVIRUS; CANCER; TUMOR; CARCINOMA; SV40; PARTICLES; INFECTION;

D O I：

10.1084/jem.20112160

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The discovery of Rous sarcoma virus, which was reported by Peyton Rous in the Journal of Experimental Medicine 100 years ago, opened the field of tumor virology. It showed that some cancers have infectious etiology, led to the discovery of oncogenes, and laid the foundation for the molecular mechanisms of carcinogenesis. Rous spent his entire research career at the Rockefeller Institute, and he was the JEM's longest serving editor. Here, we comment briefly on the life of this remarkable scientist and on the importance of his discoveries.

引用

页码：2351 / 2355

页数：5

共 53 条

[1]

ACHONG BG, 1971, J NATL CANCER I, V46, P299

[2]

VIRAL RNA-DEPENDENT DNA POLYMERASE - RNA-DEPENDENT DNA POLYMERASE IN VIRIONS OF RNA TUMOUR VIRUSES [J].