Chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls

被引：20

作者：

Sotgiu, S

Piana, A

Pugliatti, M

Sotgiu, A

Deiana, GA

Sgaramella, E

Muresu, E

Rosati, G

机构：

[1] Univ Sassari, Inst Clin Neurol, I-07100 Sassari, Italy

[2] Univ Sassari, Ist Igiene & Med Prevent, I-07100 Sassari, Italy

[3] Univ Sassari, Ist Neurochirurg, I-07100 Sassari, Italy

来源：

MULTIPLE SCLEROSIS | 2001年 / 7卷 / 06期

关键词：

Chlamydia pneumoniae; cerebrospinal fluid; multiple sclerosis; polymerase chain reaction;

D O I：

10.1177/135245850100700605

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chlamydia pneumoniae infection is a common event in neurological patients and recovery of C. pneumoniae DNA in the cerebrospinal fluids (CSF) of multiple sclerosis (MS) patients could represent an epiphenomenon. We assessed the relevance of C. pneumoniae infection in 62 CSF samples from 32 MS patients and 30 neurological controls by means of PCR, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. Multiple sclerosis (9.3%) and neurological controls (13.3) had similar percentage of anti-C. pneumoniae antibodies. However, C. pneumoniae DNA was only detectable in MS patients' CSF (9.3%). Our data support the hypothesis that C. pneumoniae persistence in some MS patients may be the result of an impaired clearance within the central nervous system.

引用

页码：371 / 374

页数：4

共 19 条

[1] Failure to detect Chlamydia pneumoniae in the central nervous system of patients with MS [J].