Bio-inspired synthetic receptor molecules towards mimicry of vancomycin

被引：29

作者：

Monnee, MCF ^{[1
]}

Brouwer, AJ ^{[1
]}

Verbeek, LM ^{[1
]}

van Wageningen, AMA ^{[1
]}

Liskamp, RMJ ^{[1
]}

机构：

[1] Univ Utrecht, Utrech Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)00237-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A 512-member library of bio-inspired synthetic receptor molecules was prepared featuring a triazacyclophane scaffold. The purpose of this scaffold was to orient three (identical) peptide 'binding arms' in order to mimic an antibiotic binding cavity as is present in the vancomycin antibiotics. The library was screened with D-Ala-D-Ala and D-Ala-D-Lac containing ligands, which are present in the cell wall precursors of pathogenic bacteria. Screening and validation led to identification of a synthetic receptor capable of binding these ligands. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1521 / 1525

页数：5

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