Cross-Presentation of Tumor Antigens Is Ruled by Synaptic Transfer of Vesicles among Dendritic Cell Subsets

被引：21

作者：

Balan, Sreekumar ^{[1
]}

Bhardwaj, Nina ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[2] Parker Inst Canc Immunotherapy, San Francisco, CA 94129 USA

来源：

CANCER CELL | 2020年 / 37卷 / 06期

关键词：

TRAFFICKING; ACTIVATION;

D O I：

10.1016/j.ccell.2020.05.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Migratory dendritic cells (DCs) in tumors transport antigens and share them with lymph node resident DCs through cross-presentation. In this issue of Cancer Cell, Ruhland et al. demonstrate that transport and transfer of tumor antigens in vesicles is a dominant pathway to load resident DCs for presentation to T cells.

引用

页码：751 / 753

页数：3

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