Expression of activated transcription factor nuclear Factor-κB in periodontally diseased tissues

被引:39
作者
Ambili, R [1 ]
Santhi, WS
Janam, P
Nandakumar, K
Pillai, MR
机构
[1] Govt Dent Coll, Dept Periodont, Thiruvananthapuram 695011, Kerala, India
[2] Reg Canc Ctr, Dept Mol Med, Thiruvananthapuram, Kerala, India
关键词
immune response; inflammatory response; NF kappa B; periodontitis/prevention and control;
D O I
10.1902/jop.2005.76.7.1148
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: Chronic periodontitis is an inflammatory disease found mainly in adults. Little is known about molecular level changes associated with host response in this condition. Nuclear factor-kappa B (NF-kappa B) is a transcription factor implicated in immune and inflammatory responses. NF-kappa B activation has also been reported to be associated with many chronic inflammatory diseases. The purpose of this paper was to compare the nuclear and cytoplasmic expression of NF-kappa B transcription factor (p50/p65) and cytoplasmic expression of licB in periodontal tissues of periodontitis patients and controls. Methods: Twenty patients with chronic periodontitis and 20 healthy controls were included in the study. Gingival tissues taken during extraction were processed for immunohistochemical staining and evaluation. Results: Nuclear (activated) p50 was found in 90% of periodontal patient tissues compared to only 30% of healthy tissues. A more significant result was obtained with p65 (75% versus 5%). Intense cytoplasmic immunoreactivity was also observed in periodontitis tissues. licB, the inhibitor of NF-kappa B, was expressed only in 5% of periodontally diseased tissues. Conclusion: Activation of NF-kappa B (p50/p65) is significant in periodontally diseased tissues, suggesting the potential of inhibitors of NF-kappa B in managing periodontitis.
引用
收藏
页码:1148 / 1153
页数:6
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