A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)

被引：75

作者：

Ambudkar, SV ^{[1
]}

Sauna, ZE ^{[1
]}

Gottesman, MM ^{[1
]}

Szakacs, G ^{[1
]}

机构：

[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.tips.2005.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intercellular transfer of proteins is a mode of communication between cells that is crucial for certain physiological processes. Chemotherapy is the treatment of choice for similar to 50% of all cancers. However, multidrug resistance mediated by drug-efflux pumps such as P-glycoprotein (Pgp) minimizes the effectiveness of such therapy in a large number of patients. A new study demonstrates the functional intercellular transfer of Pgp. Non-genetic transfer of the multidrug resistance phenotype raises fascinating questions about the mechanism and regulation of cell-surface membrane-protein-mediated spread of traits.

引用

页码：385 / 387

页数：3

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