Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

被引：99

作者：

Johnston, AM ^{[1
]}

Pirola, L ^{[1
]}

Van Obberghen, E ^{[1
]}

机构：

[1] INSERM, U145, IFR 50, Fac Med, Nice, France

来源：

FEBS LETTERS | 2003年 / 546卷 / 01期

关键词：

insulin; signalling; IRS; SOCS; phosphorylation;

D O I：

10.1016/S0014-5793(03)00438-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated - both positively and negatively - at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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页码：32 / 36

页数：5

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