Role of heregulin in human cancer

被引：77

作者：

Breuleux, M. ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 18期

关键词：

heregulin; growth factor; signaling strategies; ErbB; tumorigenesis;

D O I：

10.1007/s00018-007-7120-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor tyrosine kinases, is involved in cell proliferation, invasion, survival and differentiation of normal and malignant tissues. The HRG gene family consists of four members: HRG-1, HRG-2, HRG-3 and HRG-4, of which a multitude of different isoforms are synthesized by alternative exon splicing, showing various tissue distribution and biological activities. Disruption of the physiological balance between HRG ligands and their ErbB receptors is implicated in the formation of a variety of human cancers. The general mechanisms involved in HRG-induced tumorigenesis is discussed.

引用

收藏

页码：2358 / 2377

页数：20

相关论文

共 236 条

[1] Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma [J].

Abd El-Rehim, DM ;

Pinder, SE ;

Paish, CE ;

Bell, JA ;

Rampaul, RS ;

Blamey, RW ;

Robertson, JFR ;

Nicholson, RI ;

Ellis, IO .

BRITISH JOURNAL OF CANCER, 2004, 91 (08) :1532-1542

[2] Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase [J].

Adam, L ;

Vadlamudi, R ;

Kondapaka, SB ;

Chernoff, J ;

Mendelsohn, J ;

Kumar, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (43) :28238-28246

[3] THE HEREGULIN GENE CAN BE INCLUDED IN THE 8P12 AMPLIFICATION UNIT IN HUMAN BREAST-CANCER [J].

ADELAIDE, J ;

PENAULTLLORCA, F ;

DIB, A ;

YARDEN, Y ;

JACQUEMIER, J ;

BIRNBAUM, D .

GENES CHROMOSOMES & CANCER, 1994, 11 (01) :66-69

[4] The solution structure of heregulin-α and a N-terminal mutant with suppressed activity [J].

Adler, M ;

Thompson, SA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 256 (01) :156-161

[5] Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells [J].

Aguilar, Z ;

Akita, RW ;

Finn, RS ;

Ramos, BL ;

Pegram, MD ;

Kabbinavar, FF ;

Pietras, RJ ;

Pisacane, P ;

Sliwkowski, MX ;

Slamon, DJ .

ONCOGENE, 1999, 18 (44) :6050-6062

[6] The transmembrane heregulin precursor is functionally active [J].

Aguilar, Z ;

Slamon, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (47) :44099-44107

[7]

Al Moustafa AE, 1999, ANTICANCER RES, V19, P481

[8]

ALIMANDI M, 1995, ONCOGENE, V10, P1813

[9] The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions [J].

Alroy, I ;

Yarden, Y .

FEBS LETTERS, 1997, 410 (01) :83-86

[10] Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment [J].

Arasada, RR ;

Carpenter, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (35) :30783-30787

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