Intrathecal administration of sodium nitroprusside, a nitric oxide donor, increases blood pressure in anesthetized rats

被引：28

作者：

Lee, SB ^{[1
]}

Koh, HC ^{[1
]}

Kim, ON ^{[1
]}

Sung, KW ^{[1
]}

Kim, SY ^{[1
]}

机构：

[1] HANYANG UNIV,COLL MED,DEPT PHARMACOL,SEOUL 133791,SOUTH KOREA

来源：

NEUROSCIENCE LETTERS | 1996年 / 203卷 / 01期

关键词：

nitric oxide; sodium nitroprusside; spinal cord; blood pressure; rat;

D O I：

10.1016/0304-3940(95)12269-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was performed to investigate the role of spinal nitric oxide (NO) in the central regulation of blood pressure (BP). Experiments were carried out in anesthetized artificially ventilated male Wistar rats. Intrathecal (i.t.) administration of drugs was made at the thoracic spinal level. I.t, injection of a NO donor, sodium nitroprusside (SNP; 1, 5, and 15 nmol) increased BP dose-dependently. Intrathecal pretreatment of methylene blue (209 nmol) significantly attenuated the presser response evoked by SNP (15 nmol, i.t.).I.t. administration of nitric oxide synthase inhibitor, N-G-nitro-L-arginine methyl ester (100 and 1000 nmol), caused decreases in BP. These results suggest that NO plays a tonic excitatory role in the central regulation of BP in the rat spinal cord.

引用

页码：53 / 56

页数：4

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