The maximally attainable Vo2 during exercise in humans:: the peak vs. maximum issue

The quantification of maximum oxygen uptake ((V)over dotO(2 max)), a parameter characterizing the effective integration of the neural, cardiopulmonary, and metabolic systems, requires oxygen uptake ((V)over dot(O2)) to attain a plateau. We were interested in whether a (V)over dotO(2) plateau was consistently manifest during maximal incremental ramp cycle ergometry and also in ascertaining the relationship between this peak (V)over dotO(2) ((V)over dotO(2 peak)) and that determined from one, or several, maximal constant-load tests. Ventilatory and pulmonary gas-exchange variables were measured breath by breath with a turbine and mass spectrometer. On average, (V)over dotO(2 peak) [3.51 +/- 0.8 (SD) l/min] for the ramp test did not differ from that extrapolated from the linear phase of the response in 71 subjects. In 12 of these subjects, the (V)over dotO(2 peak) was less than the extrapolated value by 0.1-0.4 l/min (i.e., a "plateau"), and in 19 subjects, (V)over dotO(2 peak) was higher by 0.05-0.4 l/min. In the remaining 40 subjects, we could not discriminate a difference. The (V)over dotO(2 peak) from the incremental test also did not differ from that of a single maximum constant-load test in 38 subjects or from the (V)over dotO(2 max) in 6 subjects who undertook a range of progressively greater discontinuous constant-load tests. A plateau in the actual (V)over dotO(2) response is therefore not an obligatory consequence of incremental exercise. Because the peak value attained was not different from the plateau in the plot of (V)over dotO(2) vs. work rate ( for the constant-load tests), the (V)over dotO(2 peak) attained on a maximum-effort incremental test is likely to be a valid index of (V)over dotO(2 max), despite no evidence of a plateau in the data themselves. However, without additional tests, one cannot be certain.