Medial nigral dopamine neurons have rich neurotrophin support in humans

被引：54

作者：

Nishio, T

Furukawa, S

Akiguchi, I

Sunohara, N

机构：

[1] Natl Ctr Neurol & Psychiat, Dept Neurol, Kodaira, Tokyo 187, Japan

[2] Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 6068501, Japan

[3] Kyoto Univ, Fac Med, Dept Integrat Brain Sci, Sakyo Ku, Kyoto 6068501, Japan

[4] Gifu Pharmaceut Univ, Dept Mol Biol, Gifu 502, Japan

来源：

NEUROREPORT | 1998年 / 9卷 / 12期

关键词：

autocrine/paracrine; BDNF; dopamine; immunohistochemistry; neurotrophins; NGF; NT-3; Parkinson's disease; substantia nigra; trk;

D O I：

10.1097/00001756-199808240-00030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To assess the action of neurotrophin in human dopaminergic neurons, we studied the immunolocalization of neurotrophins or trks in human substantia nigra pars compacta (SNc). The neuromelanin-containing neurons in the SNc showed immunoreactivities for neurotrophins or trks, suggesting an autocrine/paracrine regulation. Quantitative analysis revealed that the percentage of those expressing NGF-like immunoreactivity (NGF-LI), BDNF-LI, NT3-LI, trkA-LI, trkB-LI, or trkC-LI was 66%, 74%, 85%, 66%, 71% or 86%, respectively. The percentage of cells expressing neurotrophins or trks was higher in the medial part than in the lateral part of the SNc. The preferential expression of neurotrophin-trk systems in the medial neurons may, at least partially, explain the differential susceptibility in Parkinson's disease. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：2847 / 2851

页数：5

共 25 条

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