Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study

被引：47

作者：

Choi, Kyung M. ^{[1
]}

Yannakoulia, Mary ^{[2
,7
]}

Park, Min S. ^{[3
]}

Cho, Geum J. ^{[4
]}

Kim, Jung H. ^{[5
]}

Lee, Seung H. ^{[6
]}

Hwang, Taik G. ^{[4
]}

Yang, Sei J.

Kim, Tai N. ^{[1
]}

Yoo, Hye J. ^{[1
]}

Baik, Sai H. ^{[1
]}

Kim, Seon M. ^{[2
,6
]}

Mantzoros, Christos S. ^{[2
,8
]}

机构：

[1] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 136705, South Korea

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

[3] Korea Univ, Coll Med, Dept Biostat, Seoul 136705, South Korea

[4] Guro Gu Publ Hlth Ctr, Seoul, South Korea

[5] Eulji Hosp, Dept Family Med, Seoul, South Korea

[6] Korea Univ, Coll Med, Dept Family Med, Seoul 136705, South Korea

[7] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece

[8] Harvard Univ, Sch Med, Boston VA Healthcare Syst, Boston, MA 02215 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2011年 / 93卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE; OBESE CHILDREN; CHILDHOOD OBESITY; RETINOL-BINDING-PROTEIN-4; OVERWEIGHT; AP2; INFLAMMATION; ADOLESCENTS; PREVALENCE;

D O I：

10.3945/ajcn.2010.29667

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background: Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults. Objective: We evaluated the association of A-FABP, RBP4, and adiponectin with the metabolic syndrome in Korean boys. Design: In this prospective cohort study, 159 boys participated in a school-based health examination and were followed up after 3 y. The metabolic syndrome in children was defined by using the pediatric adaptation of the National Cholesterol Education Program criteria. Results: Compared with normal-weight participants, overweight children had significantly higher A-FABP (23.6 +/- 8.2 compared with 12.8 +/- 5.1 mu g/L, P<0.001) and RBP4 (69.3 +/- 17.1 compared with 59.7 +/- 15.3 mu g/mL, P = 0.001) concentrations and significantly lower adiponectin concentrations (11.5 +/- 5.4 compared with 18.1 +/- 8.4 mu g/mL, P<0.001). Baseline A-FABP concentrations were significantly higher in children who developed the metabolic syndrome than in those who did not, whereas adiponectin concentrations were significantly lower. Baseline RBP4 concentrations were not significantly different between the 2 groups. Multiple logistic regression analysis showed that only A-FABP was an independent predictor of the development of the metabolic syndrome after adjustment for Tanner stage, insulin resistance, body mass index, sleep duration, and physical activity (odds ratio: 17.3; 95% CI: 1.25, 239.76; highest compared with lowest tertile), whereas the significant association between adiponectin and the metabolic syndrome observed by using bivariate analysis reflects, in part, an underlying association with obesity. Conclusion: A-FABP predicts the development of the metabolic syndrome independently of pubertal status, adiposity, and insulin resistance in Korean boys. Am J Clin Nutr 2011;93:19-26.

引用

页码：19 / 26

页数：8

共 47 条

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The increase of fatty acid-binding protein aP2 in overweight and obese children: interactions with dietary fat and impact on measures of subclinical inflammation [J].