Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine

被引：13

作者：

Anderson, J

Fishbourne, E

Corteyn, A

Donaldson, AI

机构：

[1] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England

[2] Univ Liverpool, Fac Vet Sci, Leahurst CH64 7TE, Neston, England

来源：

VACCINE | 2000年 / 19卷 / 7-8期

关键词：

rinderpest; dry powder vaccine; intra-nasal vaccination;

D O I：

10.1016/S0264-410X(00)00228-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID50 of virus per dose administered intranasally to cattle induced high titre circulating antibody responses and protection against challenge with a virulent strain of rinderpest virus. A reduction in the dose of virus to 10(1.1) TCID50 resulted in a failure to elicit detectable antibody responses and a lack of protection. Intranasal powder vaccine offers several advantages over conventional needle-administered aqueous rinderpest vaccine, including greater stability in the absence of a cold chain, reduced risk of 'needle transfer' of other microbial agents present in the vaccinated herd and lower cost. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：840 / 843

页数：4

共 15 条

[1] THE DETECTION OF ANTIBODIES AGAINST PESTE DES PETITS RUMINANTS VIRUS IN CATTLE, SHEEP AND GOATS AND THE POSSIBLE IMPLICATIONS TO RINDERPEST CONTROL PROGRAMS [J].