IgE-mediated allergy to recombinant human insulin in a diabetic

被引：11

作者：

Baur, X

Bossert, J

Koops, F

机构：

[1] Ordinariat & Zent Inst Arbeitsmed Hamburg, D-22083 Hamburg, Germany

[2] Gemeinschaftspraxis Mannheim, Mannheim, Germany

来源：

ALLERGY | 2003年 / 58卷 / 07期

关键词：

insulin allergy; protamine allergy; IgE antibodies; urticaria; skin testing;

D O I：

10.1034/j.1398-9995.2003.00128.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A 63-year-old nonatopic female suffering from type II diabetes with severe local and systemic immediate-type allergic reactions to injections of different recombinant human insulin products has been reported. Skin testing as well as IgE measurements not only proved immediate-type sensitization to human insulin but also to porcine and bovine insulin which had never been administered and indicated immunological cross-reactivity. Cross-reactivity was proved by an IgE inhibition test. Independent of this reaction, the patient showed IgE-mediated sensitization to protamine.

引用

页码：676 / 678

页数：3

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