The therapeutic potential of carbon monoxide

被引：1481

作者：

Motterlini, Roberto ^{[2
]}

Otterbein, Leo E. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Life Sci Blackfan Circle 3,Dept Surg,Transpla, Boston, MA 02215 USA

[2] Italian Inst Technol, Genoa, Italy

来源：

NATURE REVIEWS DRUG DISCOVERY | 2010年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

ISCHEMIA-REPERFUSION INJURY; PROTEIN-KINASE PATHWAY; CO-RELEASING MOLECULE; HEPATIC ISCHEMIA/REPERFUSION INJURY; CARDIAC MITOCHONDRIAL BIOGENESIS; CHRONIC ALLOGRAFT NEPHROPATHY; ENDOTHELIAL-CELL APOPTOSIS; OXYGENASE-1 GENE PROMOTER; INDUCED LUNG INJURY; EX-VIVO APPLICATION;

D O I：

10.1038/nrd3228

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin, bilirubin and ferrous iron, the haem oxygenase 1 system also has an obligatory role in the regulation of the stress response and in cell adaptation to injury. This Review provides an overview of the physiology of CO, summarizes the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation, and discusses the development and therapeutic options for the exploitation of this simple gaseous molecule.

引用

页码：728 / U24

页数：16

共 180 条

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