Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder

被引:16
作者
Ujike, H
Yamamoto, A
Tanaka, Y
Takehisa, Y
Takaki, M
Taked, T
Kodama, M
Kuroda, S
机构
[1] Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 7008558, Japan
[2] Takaoka Hosp, Himeji, Hyogo, Japan
[3] Zikei Hosp, Okayama, Japan
关键词
hSKCA3; anticipation; trinucleotide repeat; potassium channel;
D O I
10.1016/S0165-1781(01)00229-3
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
To investigate a possible involvement of expanded triplet repeats of genome in the genomes of patients with endogenous psychoses, we examined a CAG repeat polymorphism in the coding region of the KCNN3 gene in schizophrenia, schizoaffective disorder, bipolar disorder and controls of the Japanese population. There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:203 / 207
页数:5
相关论文
共 18 条
[1]  
Antonarakis SE, 1999, AM J MED GENET, V88, P348, DOI 10.1002/(SICI)1096-8628(19990820)88:4<348::AID-AJMG11>3.3.CO
[2]  
2-E
[3]   IMPRINTING AND ANTICIPATION - ARE THEY RELEVANT TO GENETIC-STUDIES OF SCHIZOPHRENIA [J].
ASHERSON, P ;
WALSH, C ;
WILLIAMS, J ;
SARGEANT, M ;
TAYLOR, C ;
CLEMENTS, A ;
GILL, M ;
OWEN, M ;
MCGUFFIN, P .
BRITISH JOURNAL OF PSYCHIATRY, 1994, 164 :619-624
[4]  
BASSETT AS, 1994, AM J HUM GENET, V54, P864
[5]   No evidence for involvement of KCNN3 (hSKCa3) potassium channel gene in familial and isolated cases of schizophrenia [J].
Bonnet-Brilhault, F ;
Laurent, C ;
Campion, D ;
Thibaut, F ;
Lafargue, C ;
Charbonnier, F ;
Deleuze, JF ;
Ménard, JF ;
Jay, M ;
Petit, M ;
Frebourg, T ;
Mallet, J .
EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (02) :247-250
[6]   Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia [J].
Bowen, T ;
Guy, CA ;
Craddock, N ;
Cardno, AG ;
Williams, NM ;
Spurlock, G ;
Murphy, KC ;
Jones, LA ;
Gray', M ;
Sanders, RD ;
McCarthy, G ;
Chandy, KG ;
Fantino, E ;
Kalman, K ;
Gutman, GA ;
Gargus, JJ ;
Williams, J ;
McGuffin, P ;
Owen, MJ ;
O'Donovan, MC .
MOLECULAR PSYCHIATRY, 1998, 3 (03) :266-269
[7]  
Chan P, 1998, ENVIRONM ENGN, V3, P3
[8]   hKCa3/KCNN3 potassium channel gene:: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21 [J].
Dror, V ;
Shamir, E ;
Ghanshani, S ;
Kimhi, R ;
Swartz, M ;
Barak, Y ;
Weizman, R ;
Avivi, L ;
Litmanovitch, T ;
Fantino, E ;
Kalman, K ;
Jones, EG ;
Chandy, KG ;
Gargus, JJ ;
Gutman, GA ;
Navon, R .
MOLECULAR PSYCHIATRY, 1999, 4 (03) :254-260
[9]  
Guy CA, 1999, AM J MED GENET, V88, P57, DOI 10.1002/(SICI)1096-8628(19990205)88:1<57::AID-AJMG10>3.0.CO
[10]  
2-6